氯丙嗪代谢VIII：精神分裂症患者体内氯丙嗪及其亚砜的血药浓度
Chlorpromazine metabolism VIII: blood levels of chlorpromazine and its sulfoxide in schizophrenic patients.
作者信息
Kaul P N, Whitfield L R, Clark M L
出版信息
J Pharm Sci. 1976 May;65(5):694-7. doi: 10.1002/jps.2600650516.
PMID:6774
Abstract
A procedure was standardized for extracting chloropromazine and its sulfoxide from the blood and for applying a recently developed fluorometric assay method to determine blood levels of these two compounds in schizophrenic patients receiving chlorpromazine therapy. The described methodology opens avenues for performing bioavailability and generic equivalence studies in humans.
摘要
已制定了一种标准化程序，用于从血液中提取氯丙嗪及其亚砜，并应用一种最近开发的荧光测定法来测定接受氯丙嗪治疗的精神分裂症患者血液中这两种化合物的水平。所描述的方法为在人体中进行生物利用度和仿制药等效性研究开辟了途径。
Zotero 插件