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麦角酸二乙酰胺:其对突触作用的形态学研究

Lysergic acid diethylamide: morphological study of its effect on synapses.

作者信息

Kemali M, Kemali D

出版信息

Psychopharmacology (Berl). 1980;69(3):315-7. doi: 10.1007/BF00433103.

DOI:10.1007/BF00433103
PMID:6774374
Abstract

A morphometric analysis of the effect of LSD on synapses was performed in the habenulae and the interpeduncular nucleus of the frog. The OsO4-fixed nervous tissue was treated with ethanol phosphotungstic acid (EPTA). Intersection of lattice lines with synapses were counted as a proportion of the total length of lines. LSD-treated frogs had a higher total area of synaptic contact than control frogs. Exocytosis profiles were observed only in LSD-treated frogs Other qualitative changes in the ultrastructural characteristic of synapses were appreciable after LSD administration.

摘要

对青蛙缰核和脚间核中LSD对突触影响进行了形态计量分析。用乙醇磷钨酸(EPTA)处理经四氧化锇固定的神经组织。将晶格线与突触的交叉点计数为线总长度的比例。用LSD处理的青蛙的突触接触总面积高于对照青蛙。仅在用LSD处理的青蛙中观察到胞吐作用特征。在给予LSD后,突触超微结构特征的其他定性变化也很明显。

相似文献

1
Lysergic acid diethylamide: morphological study of its effect on synapses.麦角酸二乙酰胺:其对突触作用的形态学研究
Psychopharmacology (Berl). 1980;69(3):315-7. doi: 10.1007/BF00433103.
2
Melatonin and LSD induce similar retinal changes in the frog.褪黑素和麦角酸二乙酰胺在青蛙体内会引发相似的视网膜变化。
Biol Psychiatry. 1986 Aug;21(10):981-5. doi: 10.1016/0006-3223(86)90276-3.
3
Action of LSD on raphe neurons and effect on presumed serotonergic raphe synapses.麦角酸二乙酰胺对中缝核神经元的作用及其对假定的中缝核5-羟色胺能突触的影响。
Brain Res. 1976 Jul 9;110(2):417-24. doi: 10.1016/0006-8993(76)90419-4.
4
The frog neuron Nissl substance, nucleus, and nucleolus after intravenous injection of lysergic acid diethylamide.
Biol Psychiatry. 1982 Sep;17(9):1023-9.
5
[Preliminary electron microscopy studies on the limbic system of Rana esculenta during chronic treatment with lysergic acid diethylamide].[对用麦角酸二乙酰胺进行慢性处理的食用蛙边缘系统的初步电子显微镜研究]
Acta Neurol (Napoli). 1974 Sep-Oct;29(5):465-85.
6
Selective effects of LSD and hyperthermia on the synthesis of synaptic proteins and glycoproteins.麦角酸二乙酰胺(LSD)和体温过高对突触蛋白及糖蛋白合成的选择性作用。
Brain Res. 1981 Feb 23;207(1):129-45. doi: 10.1016/0006-8993(81)90683-1.
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Electrophysiological analysis of psychotogenic drug action. II. General nature of lysergic acid diethylamide (LSD) action on central synapses.致幻药物作用的电生理分析。II. 麦角酸二乙酰胺(LSD)对中枢突触作用的一般性质。
AMA Arch Neurol Psychiatry. 1956 Feb;75(2):132-43.
8
LSD and CNS transmission.麦角酸二乙酰胺与中枢神经系统传递
Annu Rev Pharmacol. 1972;12:157-68. doi: 10.1146/annurev.pa.12.040172.001105.
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Hyperthermic effects of D-lysergic acid diethylamide (LSD) and its derivatives in rabbits and rats.麦角酸二乙酰胺(LSD)及其衍生物对家兔和大鼠的热效应
Arch Int Pharmacodyn Ther. 1977 Aug;228(2):314-21.
10
Dual actions of lysergic acid diethylamide tartrate (LSD), 2-bromo-D-lysergic acid diethylamide bitartrate (BOL) and methysergide on dorsal root potentials evoked by stimulation of raphe nuclei.酒石酸麦角酸二乙酰胺(LSD)、2-溴-D-麦角酸二乙酰胺酒石酸盐(BOL)和甲基麦角新碱对刺激中缝核诱发的背根电位的双重作用。
J Pharmacol Exp Ther. 1981 Apr;217(1):99-104.

本文引用的文献

1
Changes in the fine structure of the neuromuscular junction of the frog caused by black widow spider venom.黑寡妇蜘蛛毒液对青蛙神经肌肉接头精细结构的影响。
J Cell Biol. 1972 Jan;52(1):1-14. doi: 10.1083/jcb.52.1.1.
2
Fine structural and cytochemical analysis of the staining of synaptic junctions with phosphotungstic acid.用磷钨酸对突触连接进行染色的精细结构和细胞化学分析。
J Ultrastruct Res. 1968 Mar;22(5):361-75. doi: 10.1016/s0022-5320(68)90027-0.
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Quantitative stereology of synapses: a critical investigation.
Brain Res. 1973 Aug 17;58(1):25-35. doi: 10.1016/0006-8993(73)90821-4.
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Synaptic changes in frog brain after stimulation with potassium chloride.用氯化钾刺激后青蛙大脑中的突触变化。
J Neurocytol. 1975 Feb;4(1):33-46. doi: 10.1007/BF01099093.
5
Morphometry of the effect of increased experience and training on synaptic density in area CA3 of the rat hippocampus.增加经验和训练对大鼠海马体CA3区突触密度影响的形态学测量
J Histochem Cytochem. 1979 Nov;27(11):1548-50. doi: 10.1177/27.11.512348.
6
Substance P containing and cholinergic projections from the habenula.来自缰核的含P物质和胆碱能投射。
Brain Res. 1978 Jun 30;149(2):413-29. doi: 10.1016/0006-8993(78)90484-5.
7
Observations on central nervous system structures following the administration of a psychotomimetic substance.关于服用拟精神病药物后中枢神经系统结构的观察
Acta Neurol (Napoli). 1979 Jun;1(3):171-6.
8
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.通过快速冷冻捕获的突触小泡胞吐作用及其与量子递质释放的关联。
J Cell Biol. 1979 May;81(2):275-300. doi: 10.1083/jcb.81.2.275.