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坦桑尼亚达累斯萨拉姆穆希姆比利国家医院三级护理中心5岁以下营养不良儿童的维生素D水平——一项横断面研究

Vitamin D Levels in Malnourished Children under 5 Years in a Tertiary Care Center at Muhimbili National Hospital, Dar es Salaam, Tanzania-A Cross-sectional Study.

作者信息

Walli Nahida Z, Munubhi Emmanuel K, Aboud Said, Manji Karim P

机构信息

Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences School of Medicine, Dar es Salaam, Tanzania.

Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

出版信息

J Trop Pediatr. 2017 Jun 1;63(3):203-209. doi: 10.1093/tropej/fmw081.

Abstract

OBJECTIVE

: To evaluate vitamin D levels/deficiency among malnourished children <5 years admitted at a tertiary care center, the Muhimbili National Hospital, Dar es Salaam, Tanzania. Children with malnutrition may have co-existing vitamin D deficiency (VDD), which may be severe.

METHODS

: Serum vitamin D and alkaline phosphatase were evaluated, and X-ray of the wrist was carried out on 134 children.

RESULTS

: VDD was found in 41 of 134 children (30.6%). The mean vitamin D level was 74.8 nmol/l. The mean alkaline phosphatase level was 176.6 U/l. Sixty-four (48%) children were found to have severe stunting, of whom 20 (31.2%) were vitamin D deficient. Marasmic children had higher odds of VDD compared with other forms of malnutrition.

CONCLUSION

: The high prevalence of VDD in malnourished children underlines the need for active surveillance and aggressive management.

摘要

目的

评估坦桑尼亚达累斯萨拉姆市穆希姆比利国家医院这一三级医疗中心收治的5岁以下营养不良儿童的维生素D水平/缺乏情况。营养不良儿童可能并存维生素D缺乏(VDD),且可能较为严重。

方法

对134名儿童进行血清维生素D和碱性磷酸酶评估,并拍摄腕部X线片。

结果

134名儿童中有41名(30.6%)存在VDD。维生素D平均水平为74.8 nmol/l。碱性磷酸酶平均水平为176.6 U/l。发现64名(48%)儿童有严重发育迟缓,其中20名(31.2%)维生素D缺乏。与其他形式的营养不良相比,消瘦型儿童发生VDD的几率更高。

结论

营养不良儿童中VDD的高患病率凸显了进行积极监测和积极管理的必要性。

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