大肠杆菌中的误差传播及其与细胞衰老的关系。
Error propagation in Escherichia coli and its relation to cellular ageing.
作者信息
Rosenberger R F, Foskett G, Holliday R
出版信息
Mech Ageing Dev. 1980 Jul;13(3):247-52. doi: 10.1016/0047-6374(80)90037-8.
PMID:6775161
Abstract
The mistranslation of alkaline phosphatase may not provide a definitive measure of errors in Escherichia coli protein synthesis. beta-Galactosidase which, unlike alkaline phosphatase, is an intracellular enzyme exhibits different mistranslation kinetics. Previous conclusions based on alkaline phosphatase data and showing no relation between error propagation and ageing may require re-evaluation.
摘要
碱性磷酸酶的错误翻译可能无法为大肠杆菌蛋白质合成中的错误提供决定性的衡量标准。与碱性磷酸酶不同，β-半乳糖苷酶是一种细胞内酶，其表现出不同的错误翻译动力学。以前基于碱性磷酸酶数据得出的、表明错误传播与老化之间没有关系的结论可能需要重新评估。
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