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在存在产生翻译错误的试剂的情况下，大肠杆菌中分解代谢阻遏对β-半乳糖苷酶合成的抑制作用。

Catabolie repression in inhibition of beta-galactosidase synthesis by Escherichia coli in the presence of agents producing translation errors.

作者信息

Artman M, Werthamer S, Gelb P

出版信息

Antimicrob Agents Chemother. 1972 Dec;2(6):449-55. doi: 10.1128/AAC.2.6.449.

DOI:10.1128/AAC.2.6.449
PMID:4596742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444338/
Abstract

Studies were made of the synthesis of beta-galactosidase by Escherichia coli in the presence of 5-fluorouracil, streptomycin, and subinhibitory concentrations of chloramphenicol. The preferential inhibition of beta-galactosidase synthesis observed in the presence of the above drugs was found to be caused by catabolite repression.

摘要

对大肠杆菌在5-氟尿嘧啶、链霉素和亚抑制浓度氯霉素存在的情况下合成β-半乳糖苷酶进行了研究。发现在上述药物存在的情况下观察到的对β-半乳糖苷酶合成的优先抑制是由分解代谢物阻遏引起的。

相似文献

1
Catabolie repression in inhibition of beta-galactosidase synthesis by Escherichia coli in the presence of agents producing translation errors.在存在产生翻译错误的试剂的情况下，大肠杆菌中分解代谢阻遏对β-半乳糖苷酶合成的抑制作用。
Antimicrob Agents Chemother. 1972 Dec;2(6):449-55. doi: 10.1128/AAC.2.6.449.
2
Effects of streptomycin deprivation on enzyme synthesis in streptomycin-dependent Escherichia coli.链霉素缺失对链霉素依赖型大肠杆菌中酶合成的影响。
J Bacteriol. 1967 Oct;94(4):1154-61. doi: 10.1128/jb.94.4.1154-1161.1967.
3
Beta-Galactosidase messenger RNA made during recovery from inhibition of protein synthesis is not translated.在从蛋白质合成抑制中恢复期间产生的β-半乳糖苷酶信使核糖核酸未被翻译。
J Biol Chem. 1976 May 10;251(9):2854-60.
4
Error propagation in Escherichia coli and its relation to cellular ageing.大肠杆菌中的误差传播及其与细胞衰老的关系。
Mech Ageing Dev. 1980 Jul;13(3):247-52. doi: 10.1016/0047-6374(80)90037-8.
5
Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.
J Mol Biol. 1966 Oct;20(3):517-26. doi: 10.1016/0022-2836(66)90007-6.
6
Involvement of the lac regulatory genes in catabolite repression in Escherichia coli.乳糖调节基因参与大肠杆菌的分解代谢物阻遏作用。
Biochem J. 1967 May;103(2):358-66. doi: 10.1042/bj1030358.
7
Action of phyenethyl alcohol on the synthesis of macromolecules in Escherichia coli.苯乙醇对大肠杆菌中大分子合成的作用。
J Bacteriol. 1966 Apr;91(4):1446-52. doi: 10.1128/jb.91.4.1446-1452.1966.
8
The messenger-directed synthesis of the alpha-fragment of the enzyme beta-galactosidase.信使指导的β-半乳糖苷酶α片段的合成。
Biochem Biophys Res Commun. 1973 Aug 6;53(3):967-74. doi: 10.1016/0006-291x(73)90186-1.
9
Polycistronic effects of catabolite repression on the lac operon.分解代谢物阻遏对乳糖操纵子的多顺反子效应。
J Bacteriol. 1972 Dec;112(3):1184-92. doi: 10.1128/jb.112.3.1184-1192.1972.
10
Catabolite repression in Escherichia coli. A study of two hypotheses.大肠杆菌中的分解代谢物阻遏：两种假说的研究
Biochem J. 1968 Nov;110(1):135-42. doi: 10.1042/bj1100135.

引用本文的文献

1
5-Fluorouracil Treatment Alters the Efficiency of Translational Recoding.5-氟尿嘧啶治疗改变翻译重编码效率。
Genes (Basel). 2017 Oct 31;8(11):295. doi: 10.3390/genes8110295.
2
Effect of cyclic guanosine 3,5-monophosphate on the synthesis of enzymes sensitive to caatabolite repression in intact cells of Escherichia coli.环磷酸鸟苷对大肠杆菌完整细胞中受分解代谢物阻遏敏感的酶合成的影响。
J Bacteriol. 1974 Nov;120(2):980-3. doi: 10.1128/jb.120.2.980-983.1974.
3
Selective inhibition of the accumulation of extracellular proteases of Pseudomonas aeruginosa by gentamicin and tobramycin.庆大霉素和妥布霉素对铜绿假单胞菌细胞外蛋白酶积累的选择性抑制作用。
Antimicrob Agents Chemother. 1985 Apr;27(4):468-72. doi: 10.1128/AAC.27.4.468.

本文引用的文献

1
CHLORAMPHENICOL-PROMOTED REPRESSION OF beta-GALACTOSIDASE SYNTHESIS IN ESCHERICHIA COLI.氯霉素对大肠杆菌中β-半乳糖苷酶合成的促进性抑制作用
Proc Natl Acad Sci U S A. 1963 Mar;49(3):400-7. doi: 10.1073/pnas.49.3.400.
2
Mutants of Escherichia coli requiring methionine or vitamin B12.需要甲硫氨酸或维生素B12的大肠杆菌突变体。
J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
3
STREPTOMYCIN-INDUCED OVERSUPPRESSION IN E. COLI.链霉素诱导的大肠杆菌过度抑制
Proc Natl Acad Sci U S A. 1964 Jun;51(6):995-1001. doi: 10.1073/pnas.51.6.995.
4
PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI.链霉素对大肠杆菌缺陷基因型的表型修复作用
Proc Natl Acad Sci U S A. 1964 Mar;51(3):487-93. doi: 10.1073/pnas.51.3.487.
5
THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI.诱导物和分解代谢物阻遏物在大肠杆菌β-半乳糖苷酶合成中的作用
J Mol Biol. 1964 Jan;8:105-27. doi: 10.1016/s0022-2836(64)80153-4.
6
Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.5-氟尿嘧啶对突变表型的逆转：一种研究信使核糖核酸中核苷酸序列的方法。
Proc Natl Acad Sci U S A. 1962 Apr 15;48(4):532-46. doi: 10.1073/pnas.48.4.532.
7
[Effects of an analog of uracil on the properties of an enzymatic protein synthesized in its presence].[尿嘧啶类似物对在其存在下合成的酶蛋白性质的影响]
C R Hebd Seances Acad Sci. 1960 Jun 13;250:4049-51.
8
Effects of fluoropyrimidines on the synthesis of bacterial proteins and nucleic acids.
J Biol Chem. 1960 Nov;235:3266-72.
9
Formation of an altered enzyme by Escherichia coli in the presence of neomycin.
J Mol Biol. 1965 Dec;14(2):619-22. doi: 10.1016/s0022-2836(65)80215-7.
10
Miscoding caused by 5-fluorouracil.由5-氟尿嘧啶引起的编码错误。
J Mol Biol. 1969 Sep 14;44(2):363-75. doi: 10.1016/0022-2836(69)90181-8.