Goodman R E, Spotts C R
J Bacteriol. 1967 Oct;94(4):1154-61. doi: 10.1128/jb.94.4.1154-1161.1967.
During growth of streptomycin-dependent strains of Escherichia coli in the absence of streptomycin (deprived growth), both constitutive and inducible synthesis of beta-galactosidase were preferentially inhibited. A similar preferential inhibition of constitutive and derepressed synthesis of alkaline phosphatase was observed. Catabolite repression accounted for part, but not all, of the inhibition of the inducible beta-galactosidase synthesis. Serological experiments indicated that that part of the inhibition specificially associated with streptomycin deprivation was not a result of the production of altered beta-galactosidase. It is suggested that during deprived growth the ribosomes of streptomycin-dependent bacteria become impaired in their ability to translate certain messages.
在无链霉素的情况下（营养剥夺生长）培养大肠杆菌的链霉素依赖菌株时，β-半乳糖苷酶的组成型合成和诱导型合成均受到优先抑制。观察到碱性磷酸酶的组成型合成和去阻遏合成也有类似的优先抑制现象。分解代谢物阻遏在一定程度上导致了诱导型β-半乳糖苷酶合成的抑制，但并非全部原因。血清学实验表明，与链霉素剥夺特异性相关的那部分抑制并非是由于产生了改变的β-半乳糖苷酶所致。有人提出，在营养剥夺生长期间，链霉素依赖型细菌的核糖体在翻译某些信息的能力上受到损害。
