Pavasuthipaisit K, Norman R L, Spies H G
Neuroendocrinology. 1980 Oct;31(4):256-60. doi: 10.1159/000123084.
The possibility that serotonin plays a role in prolactin secretion after electrical stimulation of the rhesus medial basal hypothalamus (MBH) was investigated. Prolactin responses to electrical stimulation and intravenous injection of 0.5 and 1.0 micrograms of thyrotropin-releasing hormone (TRH) were evaluated before and after administration of methysergide (MES), a serotonin receptor blocker (2 mg orally every 12 h for 48 h), and bromocriptine (CB-154), a dopamine agonist (2.5 mg orally every 12 h for 48 h). Both electrical stimulation and TRH caused prompt increases in serum prolactin. Prestimulation (basal) prolactin levels in both drug-treated groups were not significantly lower than basal levels in control groups. Pretreatment with MES significantly attenuated the electrically induced release of prolactin but had no effect on the TRH-induced release; CB-154 blocked prolactin release induced by both types of stimulation. The study reported here has provided evidence of a possible role for hypothalamic serotinin in releasing pituitary prolactin.
研究了血清素在电刺激恒河猴内侧基底下丘脑（MBH）后催乳素分泌中发挥作用的可能性。在给予5-羟色胺受体阻滞剂美西麦角（MES，每12小时口服2毫克，共48小时）和多巴胺激动剂溴隐亭（CB-154，每12小时口服2.5毫克，共48小时）之前和之后，评估了催乳素对电刺激以及静脉注射0.5微克和1.0微克促甲状腺激素释放激素（TRH）的反应。电刺激和TRH均导致血清催乳素迅速升高。两个药物治疗组的刺激前（基础）催乳素水平均不显著低于对照组的基础水平。MES预处理显著减弱了电诱导的催乳素释放，但对TRH诱导的释放没有影响；CB-154阻断了两种刺激诱导的催乳素释放。此处报道的研究提供了下丘脑5-羟色胺在释放垂体催乳素中可能发挥作用的证据。
