糖尿病中心脏甘油三酯合成的调节

Regulation of heart triglyceride synthesis in diabetes.

作者信息

Murthy V K, Shipp J C

出版信息

Adv Myocardiol. 1980;2:71-9.

Abstract

Heart triglyceride content and triglyceride synthesis were studied in control, ketotic diabetic, and insulin-treated rats. Heart triglyceride content was increased in the ketotic diabetic state but was reversed to control values on insulin treatment of the diabetic rats. Triglyceride synthesis in heart homogenates was sensitive to incubation temperature. Triglyceride synthesis from [U-14C]sn-glycero-3-phosphate was increased in the diabetic state, suggesting that increased synthesis played a role in heart triglyceride accumulation. The addition of the end product of triglyceride synthesis, e.g., triolein, to incubation mixtures resulted in inhibition of triglyceride synthesis in heart homogenates of control and diabetic rats. The results suggested that the enzymes of heart triglyceride synthesis were less sensitive to feedback inhibition in the diabetic state.

摘要

在对照大鼠、酮症糖尿病大鼠和胰岛素治疗的大鼠中研究了心脏甘油三酯含量和甘油三酯合成。在酮症糖尿病状态下心脏甘油三酯含量增加，但对糖尿病大鼠进行胰岛素治疗后可恢复到对照值。心脏匀浆中的甘油三酯合成对孵育温度敏感。糖尿病状态下由[U-14C]sn-甘油-3-磷酸合成的甘油三酯增加，表明合成增加在心脏甘油三酯积累中起作用。向孵育混合物中添加甘油三酯合成的终产物，如三油精，可导致对照大鼠和糖尿病大鼠心脏匀浆中甘油三酯合成受到抑制。结果表明，糖尿病状态下心脏甘油三酯合成的酶对反馈抑制的敏感性较低。