Csongrady A, Ponz-Gonzalez L
Anaesthesist. 1980 May;29(5):261-5.
Of 66 patients undergoing hypotensive anaesthesia for oto-rhino-laryngological surgery, a sufficient low-pressure state was obtained in only 72% of patients when nitroglycerine was used. The cumulative nitroglycerine-consumption varied between 4.0 and 98.6 mg (0.05-1.698 mg/kg body weight). In 40 cases a normal or weak nitroglycerine-effect was accentuated by dihydralazine and the extend and time course of the interaction were investigated. The exceedingly marked additional effect of this substance indicates a mutual potentiation of both drugs. The maximum of the dihydralazine-action appeared after 25-35 minutes. In 16 further cases dihydralazine was given intravenously before the nitroglycerine infusion as a premedication, whereby always constant and satisfactory hypotension could be produced. A disadvantage of these combinations, occurring in several cases, was the decreased manoeuvrability of hypotension. The continuation of the long-term sodium nitroprusside-hypotension by using nitroglycerine was succesful. Even after nitroglycerine application longer than 3 hours (up to 6 hours) the acid-base-status remained normal.
在66例接受耳鼻喉科手术低血压麻醉的患者中，使用硝酸甘油时，仅72%的患者获得了足够的低压状态。硝酸甘油的累积消耗量在4.0至98.6毫克之间（0.05 - 1.698毫克/千克体重）。在40例患者中，双肼屈嗪增强了正常或较弱的硝酸甘油效应，并对相互作用的程度和时间进程进行了研究。该物质极其显著的额外效应表明两种药物相互增效。双肼屈嗪作用的最大值出现在25 - 35分钟后。在另外16例患者中，在输注硝酸甘油前静脉注射双肼屈嗪作为术前用药，从而总能产生持续且令人满意的低血压。这些联合用药在一些病例中出现的一个缺点是低血压的可控性降低。通过使用硝酸甘油成功延续了硝普钠长期低血压状态。即使在应用硝酸甘油超过3小时（长达6小时）后，酸碱状态仍保持正常。
