Singh B M, Strobos R J
Ann Neurol. 1980 Aug;8(2):155-60. doi: 10.1002/ana.410080205.
In 21 patients, epilepsia partialis continua (EPC) was an early symptom of nonketotic hyperglycemia and occurred during an initial phase of hyponatremia and mild hyperosmolality. EPC persisted for an average of 8 days, and its duration correlated predominantly with the degree of hyponatremia. Depression of consciousness and cessation of seizures occurred with increasing severity of hyperglycemia and hyperosmolality. In 9 patients, EPC was the first symptom leading to the diagnosis of diabetes mellitus. Four patients died of serious associated illness. The majority of the patients had evidence of a localized structural cerebral lesion. Metabolic disturbances including hyperglycemia, mild hyperosmolality, hyponatremia, and lack of ketoacidosis contribute to the development of EPC in areas of focal cerebral damage.
在21例患者中，部分性持续性癫痫（EPC）是非酮症高血糖症的早期症状，发生在低钠血症和轻度高渗血症的初始阶段。EPC平均持续8天，其持续时间主要与低钠血症的程度相关。随着高血糖症和高渗血症严重程度的增加，意识障碍和癫痫发作停止。在9例患者中，EPC是导致糖尿病诊断的首发症状。4例患者死于严重的相关疾病。大多数患者有局限性脑结构性病变的证据。包括高血糖症、轻度高渗血症、低钠血症和无酮症酸中毒在内的代谢紊乱促使局灶性脑损伤区域发生EPC。
