Whyte M P, Daniels E H, Murphy W A
Am J Med. 1985 Feb;78(2):326-32. doi: 10.1016/0002-9343(85)90444-9.
Paget's bone disease is rare in young adults. Severe osteolytic Paget's bone disease in a 28-year-old man was found to respond, clinically, biochemically, and radiographically, within one month to daily subcutaneous injections of 0.5 mg of synthetic human calcitonin. After two years of therapy, he remains asymptomatic and has no biochemical evidence of Paget's bone disease while receiving injections three times a week. Despite aggressive disease, young patients may rapidly demonstrate the same beneficial response to synthetic human calcitonin therapy as has been observed in middle-aged or elderly patients with Paget's bone disease.
佩吉特骨病在年轻人中较为罕见。一名28岁男性患有严重溶骨性佩吉特骨病，经临床、生化及影像学检查发现，每日皮下注射0.5毫克合成人降钙素，一个月内病情即有改善。经过两年治疗，他仍无症状，在每周注射三次的情况下，也没有佩吉特骨病的生化证据。尽管病情严重，但年轻患者对合成人降钙素治疗可能会迅速呈现出与中年或老年佩吉特骨病患者相同的有益反应。
