Semenov Kh Kh, Malashenko A M
Biull Eksp Biol Med. 1980 Sep;90(9):365-7.
Cytological analysis of preimplantation embryonic death in 101/HY, C57BL/6JY and CBA/lacY females crossed with hybird males F1 (BALB/cYxDBA/2Y) was carried out. Embryonic death was induced by thiophosphamide at a dose of 2 mg/kg, i. p. The maximum preimplantation death was recorded in 101/HY females (38.8%), the minimum in CBA/LacY females (21.9%). In C57BL/6JY females, the maximum preimplantation death accounted for 31.3%. Thus the same chromosome damage induced by thiophosphamide in late spermatids of F1CD2 males caused quantitative differences in embryonic mortality in females of different genotypes. The data obtained evidence that fertilized eggs are capable of repairing part of damage induced by paternal chromosomes. It was demonstrated that the preimplantation embryonic death can be used for studying strain differences from the reparative activity of mouse eggs.
对101/HY、C57BL/6JY和CBA/lacY雌性小鼠与杂交雄性F1（BALB/cYxDBA/2Y）交配后的植入前胚胎死亡进行了细胞学分析。通过腹腔注射2mg/kg的硫代磷酰胺诱导胚胎死亡。植入前死亡最多的是101/HY雌性小鼠（38.8%），最少的是CBA/LacY雌性小鼠（21.9%）。在C57BL/6JY雌性小鼠中，植入前死亡最多占31.3%。因此，硫代磷酰胺在F1CD2雄性小鼠晚期精子细胞中诱导的相同染色体损伤，在不同基因型雌性小鼠中导致了胚胎死亡率的数量差异。获得的数据证明，受精卵能够修复父本染色体诱导的部分损伤。结果表明，植入前胚胎死亡可用于研究小鼠卵子修复活性的品系差异。
