[The mutagenic effect of thioTEPA in laboratory mice. V. The influence of female genotype on the realization of dominant lethal mutations induced in male spermatids].

Hybrid male mice (F1 males derived from the cross DBA/2 X AKR) were injected intraperitoneally with thio-TEPA at a 2 mg/kg dose. The mutagenic effect was determined from the frequency of dominant lethal mutations induced in spermatids of males. The malles were mated during the second and the third week after the injection to females of the strains C57BL/6, CBA/lac and to the F1 hybrid females derived from the cross CBA X C57BL/6 differing in the frequency of spontaneous and induced aberrations in bone marrow cells. In the course of investigation of pregnant C57BL/6 females, F1 (CBA X C57BL/6) and CBA/Lac females the frequency of dominant lethals induced in late spermatidis was established to be 63.4, 54.0and 37.9% respectively. The differences were interpreted as the evidence of different rates of recovery of a certain proportion of premutational lesions of the chromosomes of sperms in fertilized eggcells of female mice. No significant differences between the groups of females were observed in case of the treatment of early spermatids. It is established that the F1 hybrids derived from the cross DBA/2X XAKR are characterized by a high mutability.