Parrillo J E, Fauci A S, Wolff S M
Ann Intern Med. 1978 Aug;89(2):167-72. doi: 10.7326/0003-4819-89-2-167.
Previous studies of patients with the hypereosinophilic syndrome have found very significant morbidity and a high mortality of 77% at 3 years. Our study analyzes the therapy and prognosis of 26 patients with the hypereosinophilic syndrome. Five patients showed no evidence of progressive organ-system dysfunction and were given no therapy; all have done well. Sixteen patients with progressive organ dysfunction were treated with corticosteroids; six of the 16 had a good response and needed no further therapy. Five patients were treated with various chemotherapeutic agents that proved to be ineffective. In eight patients who were unresponsive to corticosteroid therapy, hydroxyurea produced excellent responses in six and partial responses in two. With the above regimen, our 26 patients (including 12 with poor prognostic indicators) have had a marked increase in survival (3-year mortality of 4%) when compared with the historical control group.
先前对高嗜酸性粒细胞综合征患者的研究发现，其发病率非常高，3年死亡率达77%。我们的研究分析了26例高嗜酸性粒细胞综合征患者的治疗情况及预后。5例患者未出现进行性器官系统功能障碍的迹象，未接受治疗；目前情况均良好。16例出现进行性器官功能障碍的患者接受了皮质类固醇治疗；其中6例反应良好，无需进一步治疗。5例患者接受了各种化疗药物治疗，但证明无效。在8例对皮质类固醇治疗无反应的患者中，羟基脲使6例患者产生了良好反应，2例患者产生了部分反应。采用上述治疗方案，我们的26例患者（包括12例预后指标较差的患者）与历史对照组相比，生存率有了显著提高（3年死亡率为4%）。
