Goldberg R B
Cell Tissue Res. 1984;237(2):337-42. doi: 10.1007/BF00217153.
Androgenic steroids induce oligospermia at high doses, but few studies have assessed which cell types and spermatogenic processes are affected. Testis cell numbers and rate of differentiation were quantitatively evaluated in testosterone enanthate-treated male mice by use of histological and cell separation techniques. Reduction in the number of testicular germ cells in treated animals accounted for 40% of the total reduction of spermatozoa. Testis cells differentiated at a similar rate in treated and control animals. Spermatozoa moved to the cauda epididymidis a day earlier in testosterone-treated animals, and were lost from the cauda after only two days, rather than after the normal seven days. These results suggest that over half of the 98% reduction in sperm number in testosterone-treated animals occurred at the stage of passage through the cauda epididymidis.
高剂量雄激素类固醇会导致少精子症，但很少有研究评估哪些细胞类型和生精过程会受到影响。通过组织学和细胞分离技术，对庚酸睾酮处理的雄性小鼠的睾丸细胞数量和分化速率进行了定量评估。处理组动物睾丸生殖细胞数量的减少占精子总数减少的40%。处理组和对照组动物的睾丸细胞以相似的速率分化。在睾酮处理的动物中，精子提前一天移至附睾尾部，并且仅在两天后就从附睾尾部消失，而不是正常的七天后。这些结果表明，在睾酮处理的动物中精子数量减少98%，其中超过一半发生在通过附睾尾部的阶段。
