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可乐定和酚妥拉明对小鼠下丘脑外侧背侧和腹侧区域自我刺激行为的影响。

Effect of clonidine and phentolamine on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in mice.

作者信息

Cazala P

出版信息

Psychopharmacology (Berl). 1980;68(2):173-7. doi: 10.1007/BF00432137.

DOI:10.1007/BF00432137
PMID:6776562
Abstract

The effects of IP injections of increasing doses of clonidine and phentolamine on self-stimulation behavior (ICSS) in the dorsal and ventral regions of the lateral hypothalamus were studied in C57BL/6 mice. Clonidine specifically stimulates alpha-noradernergic receptors and has two distinct effects on ICSS. Ventral hypothalamic ICSS is immediately depressed at low doses (5 microgram/kg) whereas dorsal ICSS exhibits a discrete increase. At higher doses, ICSS is perturbed at both sites. Phentolamine is a specific blocking agent of alpha-noradrenergic receptors and depresses dorsal ICSS more than that of the ventral region. These observations clearly indicate a noradrenergic influence in the dorsal region of the hypothalamus.

摘要

在C57BL/6小鼠中，研究了腹腔注射递增剂量的可乐定和酚妥拉明对下丘脑外侧背侧和腹侧区域自我刺激行为（ICSS）的影响。可乐定特异性刺激α-去甲肾上腺素能受体，对ICSS有两种不同的作用。低剂量（5微克/千克）时，下丘脑腹侧ICSS立即受到抑制，而背侧ICSS则出现离散性增加。在较高剂量时，两个部位的ICSS均受到干扰。酚妥拉明是α-去甲肾上腺素能受体的特异性阻断剂，对背侧ICSS的抑制作用比对腹侧区域更强。这些观察结果清楚地表明去甲肾上腺素能在下丘脑背侧区域有影响。

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Effects of Lilly 110140 (flouxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse.礼来110140（氟西汀）对小鼠下丘脑外侧背侧和腹侧区域自我刺激行为的影响。
Psychopharmacology (Berl). 1980;71(2):143-6. doi: 10.1007/BF00434402.
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Modulation of rat brain alpha-adrenoreceptor populations four weeks after stimulation of the nucleus locus coeruleus.蓝斑核刺激四周后大鼠脑α-肾上腺素能受体群体的调节
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Evidence for a central noradrenaline receptor stimulation by clonidine.可乐定对中枢去甲肾上腺素受体刺激作用的证据。
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Effect of intraventricular norepinephrine on neuron activity in the medial forebrain bundle during self-stimulation behavior.脑室内注射去甲肾上腺素对自我刺激行为期间内侧前脑束神经元活动的影响。
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