阿扑吗啡对小鼠下丘脑外侧背侧和腹侧区域自我刺激行为的影响。
Effects of apomorphine on self-stimulation behaviour in dorsal and ventral area of lateral hypothalamus in mice.
作者信息
Cazala P, Cardo B
出版信息
Pharmacol Biochem Behav. 1977 Mar;6(3):363-5. doi: 10.1016/0091-3057(77)90039-9.
PMID:857259
Abstract
Intraperitoneal injections of low doses of apomorphine, a dopaminergic receptor agonist, depressed briefly, and then enhanced self-stimulation behaviour in the dorsal area of lateral hypothalamus. In contrast, only depressant effects were observed in the ventral area. These differential effects suggest the presence of a dopaminergic componant in the dorsal hypothalamic self-stimulation system.
摘要
腹腔注射低剂量的阿扑吗啡（一种多巴胺能受体激动剂），会使下丘脑外侧背侧区域的自我刺激行为先短暂受到抑制，然后增强。相比之下，在下丘脑腹侧区域仅观察到抑制作用。这些不同的效应表明下丘脑背侧自我刺激系统中存在多巴胺能成分。
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