Gormezano I, Harvey J A, Aycock E
Psychopharmacology (Berl). 1980;70(2):137-43. doi: 10.1007/BF00435304.
Three experiments were conducted to determine the effects of LSD (30 nmol/kg) in classical appetitive conditioning of the rabbit jaw movement response (JMR). In experiment 1, LSD significantly enhanced the acquisition of conditioned responses (CRs). The performance of control groups receiving unpaired presentations of the conditioned stimulus (CS) and unconditioned stimulus (UCS) demonstrated that LSD's enhancing effect on conditioning could not be attributed to an elevation in baseline responding, sensitization, or pseudoconditioning. Accordingly, experiments 2 and 3 were conducted to determine whether LSD's enhancement of conditioning could have arisen from its altering the sensory processing of either the CS or UCS, or both. In experiment 2, LSD was found to have no significant effect on the functions relating UCS magnitude to the frequency, amplitude, or number of sinusoidal peaks comprising each unconditioned response (UCR). In contrast, experiment 3 revealed that LSD significantly enhanced the frequency of CRs to an extended range of CS intensities and lowered the CS intensity threshold. It was concluded that the enhancing effect of LSD on the acquisition of CRs is attributable, at least in part, to the drug's enhancement of the sensory processing of the CS.
进行了三项实验，以确定麦角酸二乙酰胺（LSD，30纳摩尔/千克）对兔下颌运动反应（JMR）经典性条件性食欲反射的影响。在实验1中，LSD显著增强了条件反应（CR）的习得。接受条件刺激（CS）和非条件刺激（UCS）非配对呈现的对照组的表现表明，LSD对条件反射的增强作用不能归因于基线反应的提高、敏感化或假性条件反射。因此，进行了实验2和实验3，以确定LSD对条件反射的增强作用是否源于其改变了CS或UCS或两者的感觉处理。在实验2中，发现LSD对将UCS强度与构成每个非条件反应（UCR）的正弦波峰的频率、幅度或数量相关联的功能没有显著影响。相比之下，实验3表明，LSD显著提高了对扩展范围的CS强度的CR频率，并降低了CS强度阈值。得出的结论是，LSD对CR习得的增强作用至少部分归因于该药物对CS感觉处理的增强。
