Awan K J
Ann Ophthalmol. 1978 Jun;10(6):781-3.
Occurrence of intraepithelial epithelioma (Bowen's disease) of the conjunctiva in a 54-year-old white man with chronic lymphocytic leukemia and bilateral labiopalatine clefting is discussed. The lesion developed slowly during 3 years following mechanical trauma to the eye. The interrelationship between trauma, Bowen's disease, and chronic lymphocytic leukemia remains obscure. It is postulated that an altered immunologic status might be responsible for neoplastic changes in the posttraumatic healing process. Intractable lesions in a patient with abnormal immunologic system or with an already proven malignancy should be studied by excisional biopsy.
讨论了一名54岁患有慢性淋巴细胞白血病和双侧唇腭裂的白人男性结膜上皮内上皮瘤（鲍恩病）的发生情况。该病变在眼部受到机械创伤后的3年里缓慢发展。创伤、鲍恩病和慢性淋巴细胞白血病之间的相互关系仍不清楚。据推测，免疫状态改变可能是创伤后愈合过程中肿瘤性变化的原因。对于免疫系统异常或已确诊患有恶性肿瘤的患者，难治性病变应通过切除活检进行研究。
