Callen J P, Headington J
Arch Dermatol. 1980 Apr;116(4):422-6.
The relationship of Bowen's disease to internal malignancy is controversial. We have studied 72 cases of Bowen's disease and compared them with 58 cases of non-Bowen's squamous intraepidermal neoplasia (SIN). Clinical data were obtained in all cases in an attempt to identify carcinogens and to detect the occurrence of other cutaneous or internal malignancies. Internal malignancy was not found more commonly in patients with Bowen's disease than in those with other forms of SIN. However, 5.7% of all patients win SIN were found to have a concurrent internal malignancy. Other cutaneous malignancies were also more frequent in these groups and may relate to sun exposure. Evidence for arsenic ingestion was not found in most patients. We believe that SIN either as Bowen's or non-Bowen's type may serve as an important marker for the presence of internal malignancy.
鲍恩病与体内恶性肿瘤的关系存在争议。我们研究了72例鲍恩病患者，并将他们与58例非鲍恩病性鳞状上皮内瘤变（SIN）患者进行了比较。所有病例均获取了临床数据，以试图识别致癌物并检测其他皮肤或体内恶性肿瘤的发生情况。鲍恩病患者中未发现体内恶性肿瘤比其他形式SIN患者更常见。然而，所有SIN患者中有5.7%被发现同时患有体内恶性肿瘤。这些组中其他皮肤恶性肿瘤也更常见，可能与日晒有关。大多数患者未发现摄入砷的证据。我们认为，无论是鲍恩病型还是非鲍恩病型的SIN都可能作为体内恶性肿瘤存在的重要标志物。
