Herat Asoka, Shirato Kyoko, Damian Diona L, Finlayson Robert, Whitfeld Margot
Skin and Cancer Foundation, University of Sydney at Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Australas J Dermatol. 2006 May;47(2):120-3. doi: 10.1111/j.1440-0960.2006.00246.x.
A 54-year-old HIV-positive homosexual man presented with erythematous and pigmented plaques on background erythema in the perianal region, histologically consistent with Bowen's disease. Perianal Bowen's disease represents high-grade anal intraepithelial neoplasia, which is considered a precursor lesion of invasive anal squamous cell carcinoma. This patient's anal intraepithelial neoplasia was unresponsive to multiple treatment modalities including cryotherapy, serial curettage and cautery, topical 5-fluorouracil and 5-aminolaevulinic acid photodynamic therapy. He progressed to develop a poorly differentiated squamous cell carcinoma of the anus three and a half years after the Bowen's disease was diagnosed. The squamous cell carcinoma was treated with combined chemoradiation. A recurrence of high-grade anal intraepithelial neoplasia was noted 6 months after completion of chemoradiation.
一名54岁的HIV阳性同性恋男性，肛周区域出现红斑基础上的红斑性及色素沉着斑块，组织学检查符合鲍温病。肛周鲍温病代表高级别肛管上皮内瘤变，被认为是浸润性肛管鳞状细胞癌的前驱病变。该患者的肛管上皮内瘤变对多种治疗方式均无反应，包括冷冻疗法、连续刮除及烧灼、外用5-氟尿嘧啶和5-氨基酮戊酸光动力疗法。在鲍温病确诊三年半后，他进展为肛管低分化鳞状细胞癌。该鳞状细胞癌接受了放化疗联合治疗。放化疗结束6个月后，发现高级别肛管上皮内瘤变复发。
