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Covalent binding of polychlorinated biphenyls to rat liver microsomes in vitro: nature of reactive metabolites and target macromolecules.

作者信息

Shimada T, Sato R

出版信息

Toxicol Appl Pharmacol. 1980 Sep 30;55(3):490-500. doi: 10.1016/0041-008x(80)90051-4.

DOI:10.1016/0041-008x(80)90051-4
PMID:6776652
Abstract
摘要

相似文献

1
Covalent binding of polychlorinated biphenyls to rat liver microsomes in vitro: nature of reactive metabolites and target macromolecules.多氯联苯在体外与大鼠肝脏微粒体的共价结合：活性代谢产物和靶大分子的性质
Toxicol Appl Pharmacol. 1980 Sep 30;55(3):490-500. doi: 10.1016/0041-008x(80)90051-4.
2
Covalent binding in vitro of polychlorinated biphenyls to microsomal macromolecules. Involvement of metabolic activation by a cytochrome P-450-linked mono-oxygenase system.多氯联苯在体外与微粒体大分子的共价结合。细胞色素P - 450连接的单加氧酶系统参与代谢激活。
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3
Metabolism of 2,5,2' -trichloro-, 2,5,2',5' -tetrachloro-, and 2,4,5,2',5' -pentachlorobiphenyl in rat hepatic microsomal systems.大鼠肝微粒体系统中2,5,2'-三氯联苯、2,5,2',5'-四氯联苯和2,4,5,2',5'-五氯联苯的代谢
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Direct evidence that an arene oxide is a metabolic intermediate of 2,2',5,5'-tetrachlorobiphenyl.
Biochem Biophys Res Commun. 1979 Nov 28;91(2):475-83. doi: 10.1016/0006-291x(79)91546-8.
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Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes.人肝微粒体对2,2',3,3',6,6'-六氯联苯和2,2',4,4',5,5'-六氯联苯的代谢
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Xenobiotica. 1992 Nov;22(11):1275-90. doi: 10.3109/00498259209053156.
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Activation of 3,4,3',4'-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system.大鼠肝脏微粒体含细胞色素P-448的单加氧酶系统将3,4,3',4'-四氯联苯激活为与蛋白质结合的代谢产物。
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Activation of [14C] chlorobiphenyls to protein-binding metabolites by rat liver microsomes.大鼠肝微粒体将[14C]氯联苯激活为蛋白结合代谢物。
Chem Biol Interact. 1978 Mar;20(3):355-65. doi: 10.1016/0009-2797(78)90113-8.

引用本文的文献

1
Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma.多氯联苯作为肝细胞癌的起始剂。
Cancer Lett. 2013 Jun 28;334(1):46-55. doi: 10.1016/j.canlet.2012.11.041. Epub 2012 Dec 2.
2
Alterations in liver ultrastructure and induction of UDP-glucuronyltransferase in the rat following prenatal exposure to 3,4,3',4'-tetrachlorobiphenyl.大鼠产前暴露于3,4,3',4'-四氯联苯后肝脏超微结构的改变及UDP-葡萄糖醛酸基转移酶的诱导。
Arch Environ Contam Toxicol. 1984 Nov;13(6):715-21. doi: 10.1007/BF01055935.
3
Interaction of 3,4,3',4'-tetrachlorobiphenyl metabolites formed by cytochrome P-450 in vitro with rat erythrocytes.
细胞色素P-450在体外形成的3,4,3',4'-四氯联苯代谢产物与大鼠红细胞的相互作用。
Arch Toxicol. 1985 Oct;58(1):20-6. doi: 10.1007/BF00292611.
4
Potential reproductive and postnatal morbidity from exposure to polychlorinated biphenyls: epidemiologic considerations.接触多氯联苯可能导致的生殖及产后发病情况：流行病学考量
Environ Health Perspect. 1985 May;60:233-9. doi: 10.1289/ehp.8560233.
5
Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation.母乳中的多氯联苯（PCBs）和二氯二苯二氯乙烯（DDE）：母体因素及既往哺乳情况的影响
Am J Public Health. 1986 Feb;76(2):172-7. doi: 10.2105/ajph.76.2.172.