Tan M H, Dickinson M A, Albers J J, Havel R J, Cheung M C, Vigne J L
Am J Clin Nutr. 1980 Dec;33(12):2559-65. doi: 10.1093/ajcn/33.12.2559.
The effects of a high cholesterol, high saturated fat diet on serum high density lipoprotein cholesterol, apo A-I, and apo E levels were studied in six normolipidemic subjects. The study was done on an outpatient basis and mixed natural foods normally consumed by humans were used. When compared with a low cholesterol (98 mg/day) high polyunsaturated fat (P/S ratio 1.6) diet, the high cholesterol (1021 mg/day), high saturated fat (P/S ratio 0.4) diet increased serum cholesterol (23%) by raising the cholesterol concentration in very low-density lipoproteins (59%), low-density lipoproteins (15%), and high-density lipoproteins (30%). The low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol ratio fell significantly from 1.78 to 1.58. The increased high-density lipoprotein-cholesterol was associated with an elevation of serum apo A-I but not apo E. Serum triglycerides did not change significantly.
在六名血脂正常的受试者中研究了高胆固醇、高饱和脂肪饮食对血清高密度脂蛋白胆固醇、载脂蛋白A-I和载脂蛋白E水平的影响。该研究在门诊进行，使用的是人类通常食用的混合天然食物。与低胆固醇（98毫克/天）、高多不饱和脂肪（P/S比值1.6）饮食相比，高胆固醇（1021毫克/天）、高饱和脂肪（P/S比值0.4）饮食通过提高极低密度脂蛋白（59%）、低密度脂蛋白（15%）和高密度脂蛋白（30%）中的胆固醇浓度，使血清胆固醇升高了23%。低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值从1.78显著降至1.58。高密度脂蛋白胆固醇的升高与血清载脂蛋白A-I的升高有关，但与载脂蛋白E无关。血清甘油三酯没有显著变化。
