Hansen K D, Meyer R F
Arch Ophthalmol. 1980 Nov;98(11):1991-2. doi: 10.1001/archopht.1980.01020040843009.
A Pseudomonas-caused corneal ulcer developed in a 44-year-old man with severe facial and upper torso thermal burns while in the hospital burn unit. The infecting strain was resistant to most antibiotics, including gentamicin sulfate and tobramycin sulfate. Treatment with topical and parenteral amikacin sulfate resulted in rapid healing. To our knowledge, there have been no reports of the use of amikacin for corneal ulcer. The successful healing in this case suggests that the use of amikacin should be considered in the treatment of corneal ulceration when it is suspected that the pathogen is a Pseudomonas strain resistant to gentamicin and other commonly used antibiotics.
一名44岁面部和上半身严重热烧伤男子在医院烧伤科住院期间发生了由铜绿假单胞菌引起的角膜溃疡。感染菌株对包括硫酸庆大霉素和硫酸妥布霉素在内的大多数抗生素耐药。局部和胃肠外使用硫酸阿米卡星治疗后溃疡迅速愈合。据我们所知，此前尚无使用阿米卡星治疗角膜溃疡的报道。该病例的成功治愈表明，当怀疑病原体是对庆大霉素和其他常用抗生素耐药的铜绿假单胞菌菌株时，在角膜溃疡治疗中应考虑使用阿米卡星。
