O'Herlihy C, Pepperell R J, Evans J H
Br Med J. 1980 Nov 29;281(6253):1447-50. doi: 10.1136/bmj.281.6253.1447.
High serum follicle stimulating hormone (FSH) values are consistent with ovarian failure. We studied the progress of 67 women aged under 35 years with oligomenorrhoea or secondary amenorrhoea in whom the serum FSH value was greater than 20 U/1. Twenty-four patients remained amenorrhoeic, but 17 ovulated and six conceived, two on two occasions. Coincident mean serum luteinising hormone (LH) concentrations were significantly lower and mean total urinary oestrogen concentrations were significantly higher in patients who subsequently ovulated, but the degree of increase in FSH did not correlate well with later ovarian function. Treatment with oestrogens, clomiphene citrate, human pituitary gonadotrophin, and bromocriptine was of no benefit in inducing an ovarian response while FSH concentrations remained raised. Our results suggest that a considerable proportion of younger women with ovulatory disorders associated with FSH values in the menopausal range will spontaneously resume ovulation and some will conceive.
高血清促卵泡激素（FSH）值与卵巢功能衰竭相符。我们研究了67名年龄在35岁以下、患有月经过少或继发性闭经且血清FSH值大于20 U/1的女性的病情进展。24名患者仍处于闭经状态，但17名排卵，6名怀孕，其中2名怀孕两次。随后排卵的患者，其血清黄体生成素（LH）浓度均值显著较低，总尿雌激素浓度均值显著较高，但FSH升高程度与后期卵巢功能的相关性不佳。当FSH浓度持续升高时，使用雌激素、枸橼酸氯米芬、人垂体促性腺激素和溴隐亭治疗对诱导卵巢反应无效。我们的结果表明，相当一部分患有与绝经范围内FSH值相关的排卵障碍的年轻女性会自发恢复排卵，部分还会怀孕。
