Howland B E
Horm Metab Res. 1980 Oct;12(10):520-3. doi: 10.1055/s-2007-999190.
Intact (experiment 1) or castrated (experiment 2) male rats were either fed or fasted for 24 hours. Half of each group received 75 mg 2-deoxy-D-glucose/100 gm body weight, intraperitoneally. Assays of sera from blood samples obtained from intact rats 4 hr after the injection revealed that 2-deoxy-D-glucose suppressed serum testosterone levels (P < 0.05) while 2-deoxy-D-glucose plus fasting was most effective in suppressing LH and FSH. In castrates LH was suppressed by 2-deoxy-D-glucose and FSH by fasting (P < 0.01 and P < 0.05). Serum glucose was elevated 3-5 fold by 2-deoxy-D-glucose (P < 0.01). Experiments with female rats revealed that treatment with 2-deoxy-D-glucose had no effect on the rise in serum LH that followed GnRH treatment in ovariectomized, steroid-primed animals. However, progesterone-induced LH release in estrogen-primed ovariectomized rats was blocked by 2-deoxy-D-glucose. Collectively, these results suggest that glucoprivation impairs hypothalamic control of gonadotropin secretion.
对完整雄性大鼠（实验1）或去势雄性大鼠（实验2）进行24小时喂食或禁食处理。每组一半大鼠腹腔注射75毫克2-脱氧-D-葡萄糖/100克体重。对注射后4小时从完整大鼠采集的血样进行血清检测，结果显示2-脱氧-D-葡萄糖可抑制血清睾酮水平（P<0.05），而2-脱氧-D-葡萄糖加禁食对抑制促黄体生成素（LH）和促卵泡生成素（FSH）最为有效。在去势大鼠中，2-脱氧-D-葡萄糖可抑制LH，禁食可抑制FSH（P<0.01和P<0.05）。2-脱氧-D-葡萄糖可使血清葡萄糖水平升高3至5倍（P<0.01）。对雌性大鼠的实验表明，在切除卵巢并用类固醇预处理的动物中，2-脱氧-D-葡萄糖处理对促性腺激素释放激素（GnRH）处理后血清LH的升高没有影响。然而，在雌激素预处理的去势大鼠中，2-脱氧-D-葡萄糖可阻断孕酮诱导的LH释放。总体而言，这些结果表明糖缺乏会损害下丘脑对促性腺激素分泌的控制。
