Lennon H D, Metcalf L E, Mares S E, Smith J H, Nutting E F, Saunders F J
J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):375-86.
Intragastric administration of approximately 300 mg/kg/day of aspartame (APM) to female rats for seven days and to female hamsters for five days after mating did not affect postcoital fertility as measured by the number of implantation sites and normal appearing fetuses. In additional studies, the effect of APM fed at 1 to 14% in the diet to lactating rats and their litters of suckling young was studied using a pair-feeding experimental design. Levels of APM up to 4% in the diet (about 7 g/kg/day) did not affect food consumption, body weights, serum prolactin, serum gonadotropins, the mammary gland histology of the dams or the growth and survival rates of their pups. However, higher levels of 7.5 and 14% APM (about 9 g/kg/day) caused reduced food consumption due to diet palatability and resulted in body weight loss in dams and retarded growth rates in the young.
在交配后，对雌性大鼠连续7天、对雌性仓鼠连续5天进行胃内给药，剂量约为300毫克/千克/天的阿斯巴甜（APM），通过着床部位数量和外观正常的胎儿数量来衡量，并未影响交配后的生育能力。在其他研究中，采用配对喂养实验设计，研究了在哺乳期大鼠及其哺乳幼崽的饮食中添加1%至14%的APM的影响。饮食中APM含量高达4%（约7克/千克/天）时，不会影响食物摄入量、体重、血清催乳素、血清促性腺激素、母鼠的乳腺组织学或幼崽的生长和存活率。然而，APM含量较高的7.5%和14%（约9克/千克/天），由于饮食适口性导致食物摄入量减少，致使母鼠体重减轻，幼崽生长速度迟缓。
