Pani B, Babudri N, Bartoli-Klugmann F, Venturini S, di Fant I
Mutat Res. 1980 Aug;78(4):375-9. doi: 10.1016/0165-1218(80)90044-0.
3 diazoacetylglycine derivatives, diazoacetylglycine amide (DGA), diazoacetylglycine ethyl ester (DGE) and diazoacetylglycine hydrazide (DGH), known as antitumour agents, and shown to be mutagenic in bacteria, were studied for their mutagenic activity in the HGPRT system of V79 Chinese hamster cells in culture (V79/HGPRT system). All 3 drugs were highly effective in inducing 6-thioguanine-resistant mutants at concentrations that were not significantly cytotoxic.
3种重氮乙酰甘氨酸衍生物，即重氮乙酰甘氨酸酰胺（DGA）、重氮乙酰甘氨酸乙酯（DGE）和重氮乙酰甘氨酸酰肼（DGH），作为抗肿瘤药物，已证明在细菌中具有致突变性，对其在培养的V79中国仓鼠细胞的次黄嘌呤-鸟嘌呤磷酸核糖转移酶系统（V79/HGPRT系统）中的致突变活性进行了研究。所有这3种药物在浓度不具有明显细胞毒性时，都能高效诱导出对6-硫代鸟嘌呤耐药的突变体。
