Bernstein J M, Ogra P L
Ann Otol Rhinol Laryngol Suppl. 1980 May-Jun;89(3 Pt 2):326-32. doi: 10.1177/00034894800890s378.
The ontogeny of the mucosal immune system as it relates to the development of lymphoid tissue in the respiratory tract and the gastrointestinal tract has been studied quite extensively over the past few years. It is apparent now that the bronchus-associated lymphoid tissue and gut-associated lymphoid tissue are the major sources of immunocompetent precursor B lymphocytes. After the induction of antigens in the respiratory tract or the gastrointestinal tract, precursor lymphoid cells in these sites are preferentially activated to undergo significant proliferation. Such antigen-sensitized cells eventually migrate to other mucosa sites, such as mammary glands, genital tract, conjuctiva, etc. Recent evidence has suggested that the immunocompetent tissue observed in the middle ear cleft during otitis media with effusion may function as an extension of the mucosal immune system in the upper respiratory tract. The implications of these observations relative to middle ear disease are discussed.
在过去几年中，人们对黏膜免疫系统的个体发生进行了广泛研究，该过程与呼吸道和胃肠道淋巴组织的发育相关。目前很明显，支气管相关淋巴组织和肠道相关淋巴组织是具有免疫活性的前体B淋巴细胞的主要来源。在呼吸道或胃肠道诱导抗原后，这些部位的前体淋巴细胞优先被激活，从而进行显著增殖。这些抗原致敏细胞最终迁移到其他黏膜部位，如乳腺、生殖道、结膜等。最近的证据表明，在分泌性中耳炎期间中耳裂中观察到的具有免疫活性的组织可能作为上呼吸道黏膜免疫系统的延伸发挥作用。本文讨论了这些观察结果与中耳疾病的相关性。
