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[抗肿瘤抗生素卡米诺霉素和柔红霉素的比较细胞遗传学作用]

[Comparative cytogenetic action of the antitumor antibiotics, carminomycin and rubomycin].

作者信息

Kurlov O V, Koĭfman E K, Gol'dberg E D

出版信息

Antibiotiki. 1978 Jun;23(6):537-40.

PMID:677842
Abstract

A comparative mutagenic effect of karminomycin and rubomycin in LD50 on the cells of the rat bone marrow (71 animals) was studied. It was found that karminomycin had a higher and more prolonged mutagenic effect than rubomycin. Both antibiotics induced mainly chromatin deletions and not so frequent reconstructions. They are probably identical with respect to their mechanism of action on chromosomes.

摘要

研究了卡米诺霉素和柔红霉素在半数致死剂量（LD50）下对大鼠骨髓细胞（71只动物）的比较诱变作用。发现卡米诺霉素比柔红霉素具有更高且更持久的诱变作用。两种抗生素主要诱导染色质缺失，较少诱导重建。它们在对染色体的作用机制方面可能是相同的。

相似文献

1
[Comparative cytogenetic action of the antitumor antibiotics, carminomycin and rubomycin].[抗肿瘤抗生素卡米诺霉素和柔红霉素的比较细胞遗传学作用]
Antibiotiki. 1978 Jun;23(6):537-40.
2
[Myeloinhibitory effect of the action of some antitumor antibiotics and its comparative assessment].[某些抗肿瘤抗生素作用的髓抑制效应及其比较评估]
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[Comparative evaluation of the cytogenetic action of anthracycline-group antitumor antibiotics (daunomycin, doxorubicin and carminomycin)].[蒽环类抗肿瘤抗生素（柔红霉素、阿霉素和洋红霉素）细胞遗传学作用的比较评估]
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