Howe E, Howe C, Pollard I
Aust J Biol Sci. 1980 Aug;33(4):471-8. doi: 10.1071/bi9800471.
An ultrastructural study of the thyroid gland of the Snell dwarf mouse showed cellular activity to be very low. Follicle cell diameters were significantly lower than in controls whilst the nucleocytoplasmic ratio was significantly higher. The observed cellular activity of the thyroid cells was associated with circulating levels of thyroxine which were found to be significantly lower than in controls. Measurement of the free thyroxine index showed very little free hormone available for tissue uptake. No differences in thyroid function due to age or sex in the dwarf mice were seen. Possible endocrine imbalances contributing to the low thyroid activity in the Snell dwarf mouse are discussed.
对斯内尔侏儒小鼠甲状腺的超微结构研究表明，细胞活性非常低。滤泡细胞直径显著低于对照组，而核质比显著更高。观察到的甲状腺细胞活性与甲状腺素的循环水平相关，发现其显著低于对照组。游离甲状腺素指数的测量显示，可供组织摄取的游离激素很少。在侏儒小鼠中未观察到因年龄或性别导致的甲状腺功能差异。本文讨论了可能导致斯内尔侏儒小鼠甲状腺活性低下的内分泌失衡情况。
