流产布鲁氏菌45/20株可溶性抗原或全细胞与免疫佐剂相关的免疫原性。II. 全细胞。
Immunogenic properties of soluble antigens or whole cells of Brucella abortus strain 45/20 associated with immunoadjuvants. II. Whole cells.
作者信息
Woodard L F, Toone N M, McLaughlin C A
出版信息
Can J Comp Med. 1980 Oct;44(4):456-8.
Whole cells of Brucella abortus strain 45/20 were combined with trehalose dimycolate or muramyl dipeptide. These preparations were tested in guinea pigs for immunogenic properties. Both trehalose dimycolate and muramyl dipeptide were found to be effective adjuvants to whole cells when combined in oil emulsions. Although saline suspensions of whole cells or whole cells-muramyl dipeptide did not significantly reduce splenic infections, oil emulsion or whole cells-trehalose dimycolate in oil droplet emulsion were both effective immunogens (P < 0.05). Oil emulsions of whole cells-muramyl dipeptide reduced mean splenic Brucella by 95.1% and those of whole cells-trehalose dimycolate reduced mean splenic Brucella by 99.3% as compared to the control animals.
流产布鲁氏菌45/20菌株的全细胞与海藻糖二霉菌酸酯或胞壁酰二肽混合。这些制剂在豚鼠身上进行免疫原性测试。发现海藻糖二霉菌酸酯和胞壁酰二肽与全细胞混合并制成油乳剂时，都是有效的佐剂。虽然全细胞的盐悬液或全细胞-胞壁酰二肽并未显著减少脾脏感染，但油乳剂或油滴乳剂中的全细胞-海藻糖二霉菌酸酯都是有效的免疫原（P < 0.05）。与对照动物相比，全细胞-胞壁酰二肽的油乳剂使脾脏布鲁氏菌平均减少95.1%，全细胞-海藻糖二霉菌酸酯的油乳剂使脾脏布鲁氏菌平均减少99.3%。
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