Chebotarev A N, Ressner P, Selezneva T G
Genetika. 1980;16(7):1307-10.
The paper contains the results of the study on the frequency of chromosome aberrations in the cell culture of Chinese hamster under a prolonged action of low concentrations of thiophosphamide (Thph). The frequency of chromosome aberrations in the initial period somewhat increases and then keeps to a certain constant level independently on the duration of action of thiophosphamide. With the heightening of the concentration of the chemical, a sharp increase in the number of chromosome aberrations is observed, which leads to a mass dying of the cell culture. These results may be interpreted as the action of the selection against mutant cells.
该论文包含了在中国仓鼠细胞培养物中，低浓度硫代磷酰胺（Thph）长期作用下染色体畸变频率的研究结果。初始阶段染色体畸变频率有所增加，然后无论硫代磷酰胺的作用持续时间如何，都保持在一定的恒定水平。随着该化学物质浓度的升高，观察到染色体畸变数量急剧增加，这导致细胞培养物大量死亡。这些结果可解释为对突变细胞的选择作用。
