Bochkov N P, Stukalov S V, Chebotarev A N
Biull Eksp Biol Med. 1982 Aug;94(8):90-2.
Rabbit lymphocytes were treated with thiophosphamide in vivo and in vitro. In-vitro doses were calculated by multiplying thiophosphamide concentrations by the time of treatment (the doses ranged within 0-1500 mg/min/ml). In-vivo doses were calculated as integral of thiophosphamide concentration function from the time of administration till the time of blood sample collection (the doses ranged within 0-1900 mg/min/ml). It was shown that with the dose increase the rate of chromosome aberrations and the number of disruptions per cell rise exponentially in vivo and in vitro. At the same time the parameters of regression equations coincide. This evidences that thiophosphamide produces the same effect in vivo and in vitro.
兔淋巴细胞在体内和体外接受硫磷酰胺处理。体外剂量通过硫磷酰胺浓度乘以处理时间来计算（剂量范围为0 - 1500毫克/分钟/毫升）。体内剂量通过从给药时间到采集血样时间的硫磷酰胺浓度函数积分来计算（剂量范围为0 - 1900毫克/分钟/毫升）。结果表明，随着剂量增加，体内和体外染色体畸变率及每个细胞的断裂数均呈指数上升。同时，回归方程参数一致。这证明硫磷酰胺在体内和体外产生相同的效应。
