Kuzin S M, Stukalov S V, Popandopulo P G
Biull Eksp Biol Med. 1987 Mar;103(3):349-51.
Mutagenic in vivo and in vitro effects were compared quantitatively by the investigation of sister chromatid exchange (SCE) rate and chromosomal aberrations caused by thiophosphamide in macaca rhesus lymphocytes. The integral of thiophosphamide concentration in the blood or culture fluid by a certain time period was used for the estimation of the dose of mutagenic exposure. It was shown that the dose-response relationships and corresponding regression coefficients were similar when the in vivo and in vitro results were compared. The data obtained indicate the possibility for quantitative extrapolation of the results obtained in vitro on the entire organism.
通过研究硫磷酰胺对恒河猴淋巴细胞的姐妹染色单体交换（SCE）率和染色体畸变，对体内和体外诱变效应进行了定量比较。使用特定时间段内血液或培养液中硫磷酰胺浓度的积分来估计诱变暴露剂量。结果表明，比较体内和体外结果时，剂量反应关系和相应的回归系数相似。所获得的数据表明，体外获得的结果有可能在整个生物体上进行定量外推。
