Babb R R
J Clin Gastroenterol. 1980 Sep;2(3):229-31. doi: 10.1097/00004836-198009000-00004.
An immediate hypersensitivity reaction with mast cell degranulation may be of importance in the pathogenesis of ulcerative colitis. Cromolyn sodium stabilizes the mast cell membrane, and thus could have potential benefit in the treatment of this disease. The few clinical studies published to date are difficult to interpret, and have not established the therapeutic benefit of cromolyn sodium in ulcerative colitis.
伴有肥大细胞脱颗粒的速发型超敏反应可能在溃疡性结肠炎的发病机制中起重要作用。色甘酸钠可稳定肥大细胞膜,因此可能对该病的治疗具有潜在益处。迄今为止发表的少数临床研究难以解读,且尚未证实色甘酸钠对溃疡性结肠炎的治疗效果。