Shimizu A, Takahashi N, Yamawaki-Kataoka Y, Nishida Y, Kataoka T, Honjo T
Nature. 1981 Jan 15;289(5794):149-53. doi: 10.1038/289149a0.
We have determined the order of the mouse immunoglobulin gamma 1, gamma 2 b, gamma 2 a and epsilon genes by molecular cloning of overlapping chromosomal segments. The results clearly demonstrate that the order is 5'-gamma 1-(21 kilobases)-gamma 2b-(15 kilobases)-gamma 2a-(15 kilobases)-epsilon-3'. There seem to be no J regions at the 5' side of each constant region gene so far obtained except for the mu gene and these constant region genes seem to have repetitive sequences characteristic of switch (S) regions at their 5' side.
我们通过重叠染色体片段的分子克隆确定了小鼠免疫球蛋白γ1、γ2b、γ2a和ε基因的顺序。结果清楚地表明，顺序为5'-γ1-（21千碱基）-γ2b-（15千碱基）-γ2a-（15千碱基）-ε-3'。除μ基因外，目前获得的每个恒定区基因的5'端似乎都没有J区，并且这些恒定区基因在其5'端似乎具有转换（S）区特有的重复序列。
