Auditore J V, Crisona F, Patthey H, Akintonwa A
Arch Int Pharmacodyn Ther. 1978 Apr;232(2):302-8.
Rats fed a special liquid fat diet had a higher level of liver triglycerides than rats fed a normal solid chow diet. The ingestion of ethanol induces a concomitant increase in hepatic triglycerides and a depression of ATP levels. Pure adenine base administered orally produces a significant reduction of hepatic triglycerdies and partially restores ATP levels in the chronic ethanol treated rat. Comparable doses of oral ATP are not effective. Pure guanine base and GTP failed to inhibit the ethanol-induced fatty liver and ATP depression.
喂食特殊液体脂肪饮食的大鼠肝脏甘油三酯水平高于喂食正常固体食物饮食的大鼠。摄入乙醇会导致肝脏甘油三酯同时增加以及ATP水平降低。口服纯腺嘌呤碱基可使慢性乙醇处理大鼠的肝脏甘油三酯显著降低，并部分恢复ATP水平。同等剂量的口服ATP则无效。纯鸟嘌呤碱基和GTP未能抑制乙醇诱导的脂肪肝和ATP降低。
