Leclercq J F, Malergue M C, Milosevic D, Rosengarten M D, Attuel P, Coumel P
Arch Mal Coeur Vaiss. 1980;73(3):276-87.
35 patients with mitral valve prolapse (MVP) underwent investigation by Holter monitoring with computerised analysis. Ventricular arrhythmias were observed in 70% patients with MVP. There does not seem to be a close correlation between the severity of the arrhythmia and the degree of prolapse. The mechanisms of the ventricular arrhythmia are variable: two patients had the necessary criteria for ventricular reentry, at least six had parasystolic foci, protected or not from the sinus rhythm. The most severe ventricular arrhythmias are characterised by their variable morphology (but usually showing right bundle branch block), a clear diurnal rhythm, the inducing role of exercise or emotion and a greater diurnal variation of the sinus rhythm suggesting increased sympathetic tone. The results of beta blockade are better in the patients with the most marked diurnal rhythms.
35例二尖瓣脱垂（MVP）患者接受了动态心电图监测及计算机分析检查。70%的MVP患者观察到室性心律失常。心律失常的严重程度与脱垂程度之间似乎没有密切相关性。室性心律失常的机制多种多样：2例患者有室性折返的必要标准，至少6例有并行心律灶，无论是否受窦性心律保护。最严重的室性心律失常的特点是形态多变（但通常表现为右束支传导阻滞）、明显的昼夜节律、运动或情绪的诱发作用以及窦性心律的昼夜变化较大，提示交感神经张力增加。β受体阻滞剂对昼夜节律最明显的患者效果更好。
