Miller W C, Rice D L, Unger K M, Bradley B L
Crit Care Med. 1981 Jan;9(1):7-9. doi: 10.1097/00003246-198101000-00002.
After administration of monocrotaline to dogs to produce noncardiogenic pulmonary edema, one-half of the animals (controls) were treated with intermittent positive pressure breathing (IPPV), and one-half with that ventilation plus the addition of 10 cm H2O of positive end-expiratory pressure (PEEP). After 6 h, the animals treated with PEEP demonstrated significantly better arterial oxygenation and reduced AaDO2, but lung water, quantitated either postmortem or in vivo by indicator-dilution techniques, was no less than controls. Although PEEP improves gas exchange, it fails to modify the degree of pulmonary edema represent.
给狗注射野百合碱以诱发非心源性肺水肿后，将动物分为两组（对照组），一组采用间歇正压通气（IPPV）治疗，另一组在通气基础上加用10厘米水柱呼气末正压（PEEP）。6小时后，接受PEEP治疗的动物动脉氧合明显改善，AaDO2降低，但通过尸检或指示剂稀释技术在体内定量测定的肺水量并不少于对照组。尽管PEEP改善了气体交换，但它并未改变肺水肿的程度。
