Watanabe K, Yamamoto I, Oguri K, Yoshimura H
J Pharmacobiodyn. 1980 Sep;3(9):482-4. doi: 10.1248/bpb1978.3.482.
UDP-glucuronyltransferase activities for delta 8-tetrahydrocannabinol, 11-hydroxy-delta 8-tetrahydrocannabinol, cannabidiol and cannabinol were examined using liver microsomes of rabbits. The activities for cannabidiol and cannabinol were 2.5 and 19 times higher, respectively, than those for delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol. Thus, the present study supports the view that glucuronide formation plays an important role in the metabolism of cannabinol, but does only a minor role in that of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol.
使用兔肝微粒体检测了δ8 - 四氢大麻酚、11 - 羟基 - δ8 - 四氢大麻酚、大麻二酚和大麻酚的UDP - 葡萄糖醛酸基转移酶活性。大麻二酚和大麻酚的活性分别比δ8 - 四氢大麻酚和11 - 羟基 - δ8 - 四氢大麻酚的活性高2.5倍和19倍。因此，本研究支持以下观点：葡萄糖醛酸苷的形成在大麻酚的代谢中起重要作用，但在δ8 - 四氢大麻酚和11 - 羟基 - δ8 - 四氢大麻酚的代谢中仅起次要作用。
