Condon R E, Anderson M J
Arch Surg. 1978 Jul;113(7):794-7. doi: 10.1001/archsurg.1978.01370190016002.
Responding to reports that diarrhea and pseudomenbranous colitis occurred relatively frequently among patients who received clindamycin, we initiated a program of surveillance in clindamycin-treated patients, including direct examination of the colon mucosa for inflammation or pseudomembranes and a patient follow-up by a nurse-epidemiologist. Observation of 145 patients having 161 consecutive clindamycin treatment episodes determined that unexplained diarrhea (two or more stools per day) occurred in 30 patients (21%), and more severe diarrhea (five or more stools per day) occurred in 12 patients (8%). Colitis was not identified at all. The absence of pseudomembranes was confirmed by direct examination of colon mucosa in 114 patients. Development of disabling diarrhea or colitis in association with clindamycin therapy is not a universal phenomenon.
针对有报道称接受克林霉素治疗的患者中腹泻和伪膜性结肠炎相对频繁发生的情况，我们启动了一项针对接受克林霉素治疗患者的监测计划，包括直接检查结肠黏膜是否有炎症或伪膜，并由护士流行病学家对患者进行随访。对145例患者进行了161次连续的克林霉素治疗观察，结果发现30例患者（21%）出现了不明原因的腹泻（每天排便两次或更多次），12例患者（8%）出现了更严重的腹泻（每天排便五次或更多次）。未发现有结肠炎病例。通过对114例患者的结肠黏膜进行直接检查，证实未发现伪膜。与克林霉素治疗相关的致残性腹泻或结肠炎并非普遍现象。
