Unger J L, Penka W E, Lyford C
Am J Dig Dis. 1975 Mar;20(3):214-22. doi: 10.1007/BF01070724.
Four cases of clindamycin-associated colitis have recently been observed at Kansas University Medical Center. There have been a few reports in the literature of colitis associated with this antibiotic, and our 4 cases are similar to those noted previously. All had the onset of diarrhea 7-14 days following the initiation of clindamycin therapy; the diarrhea persisted for weeks after the drug was discontinued. Mucosal changes ranged from focal ulceration to pseudomembrane formation. Diarrhea in a patient on clindamycin should alert the physician to the possibility of antibiotic induced colitis, a condition with significant morbidity and occasional mortality.
堪萨斯大学医学中心最近观察到4例与克林霉素相关的结肠炎病例。文献中已有一些关于这种抗生素相关结肠炎的报道，我们的4例病例与之前报道的相似。所有病例在开始克林霉素治疗后7 - 14天出现腹泻；停药后腹泻持续数周。黏膜变化范围从局灶性溃疡到假膜形成。使用克林霉素的患者出现腹泻应提醒医生注意抗生素诱发结肠炎的可能性，这是一种具有显著发病率且偶尔会导致死亡的疾病。
