Schrier D J, Sternick J L, Allen E M, Moore V L
Nature. 1981 Jan 29;289(5796):405-7. doi: 10.1038/289405a0.
BCG can either act as an adjuvant to potentiate immunological responses or, in some cases, can induce suppression. The reasons for these differential activities are not clear but may include routes and doses of administration, as well as variable host reactivity to the agent. In this study, we have used killed BCG administered intravenously to produce chronic granulomatous inflammation (CGI) in the lungs and spleen of inbred mice. We report that strains which develop CGI were usually anergic, as evaluated by the development of delayed hypersensitivity (DH) to sheep erythrocytes (SRBC). Studies on the genetics of BCG-induced anergy indicated that it was unigenic, recessive and linked (approximately 28 recombination units) to the immunoglobulin heavy-chain allotype (Igh). There was no influence by genes linked to the major histocompatibility complex. The study indicates that anergy associated with CGI is under genetic control, which may explain the variability of anergy in patients with granulomatous diseases. The implication of linkage to the Igh complex is not clear, but it may be associated with VH receptors on T lymphocytes, which in turn act on macrophages to mediate suppression.
卡介苗（BCG）既可以作为佐剂增强免疫反应，在某些情况下也可诱导免疫抑制。产生这些不同作用的原因尚不清楚，但可能包括给药途径和剂量，以及宿主对该制剂的反应性差异。在本研究中，我们通过静脉注射灭活的卡介苗，在近交系小鼠的肺和脾脏中引发慢性肉芽肿性炎症（CGI）。我们报告称，通过对绵羊红细胞（SRBC）迟发型超敏反应（DH）的发展情况评估，发生CGI的品系通常无反应性。对卡介苗诱导的无反应性的遗传学研究表明，它是单基因的、隐性的，并且与免疫球蛋白重链同种异型（Igh）连锁（约28个重组单位）。与主要组织相容性复合体相关的基因没有影响。该研究表明，与CGI相关的无反应性受基因控制，这可能解释了肉芽肿性疾病患者无反应性的变异性。与Igh复合体连锁的意义尚不清楚，但可能与T淋巴细胞上的VH受体有关，而VH受体又作用于巨噬细胞以介导抑制作用。
