含胆固醇脂质体对肝脏胆固醇-7α-羟化酶及药物氧化系统的影响。
Effect of liposomes containing cholesterol on a hepatic cholesterol-7 a-hydroxylase and drug oxidation system.
作者信息
Deliconstantinos G
出版信息
Experientia. 1981 Jan 15;37(1):81-3. doi: 10.1007/BF01965584.
PMID:6781930
Abstract
A statistically significant increase (p less than 0.01) in the activities of the microsomal enzymes cholesterol-7 a-hydroxylase (EC 1.14.13.17), biphenyl-4-hydroxylase, aniline hydroxylase, NADPH-cytochrome-c-reductase (EC 1.6.2.4) and p-nitroanisole-O-demethylase, was shown in cholesterol-loaded rat liver microsomes. The data indicate that profound functional changes are induced in membrane proteins by exogenous cholesterol.
摘要
在胆固醇负荷的大鼠肝微粒体中，微粒体酶胆固醇-7α-羟化酶（EC 1.14.13.17）、联苯-4-羟化酶、苯胺羟化酶、NADPH-细胞色素c还原酶（EC 1.6.2.4）和对硝基苯甲醚-O-脱甲基酶的活性出现了具有统计学意义的增加（p小于0.01）。数据表明，外源性胆固醇可诱导膜蛋白发生深刻的功能变化。
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