Sovner R, Hurley A
J Nerv Ment Dis. 1981 Mar;169(3):191-5. doi: 10.1097/00005053-198103000-00007.
The authors review the medical literature and present two case histories regarding the efficacy of lithium carbonate in the treatment of chronic behavior disorders in mentally retarded adults. They conclude that the available data lend tentative support for the use of lithium to manage behavior disorders in retarded individuals which are characterized by lifelong hyperactivity, aggressiveness, and/or self-mutilation. They recommend that, when lithium is used for this indication, a blood level of approximately 1.0 mEq/1 is necessary, and that all patients be given a drug-free trial once a therapeutic effect has been achieved in order to assess the continued need for treatment. Etiological issues, a possible mechanism of action involving lithium's effect on CNS serotonergic activity, and areas for future research are discussed.
作者回顾了医学文献，并给出了两个关于碳酸锂治疗成年智力迟钝者慢性行为障碍疗效的病例史。他们得出结论，现有数据为使用锂盐治疗以终生多动、攻击性和/或自残为特征的智力迟钝者的行为障碍提供了初步支持。他们建议，当锂盐用于这一适应症时，血液水平约为1.0毫当量/升是必要的，并且一旦取得治疗效果，所有患者都应进行停药试验，以评估是否继续需要治疗。文中还讨论了病因问题、锂盐对中枢神经系统血清素能活性影响的可能作用机制以及未来研究的领域。
