Efira A, van Laethem Y, Ectors M, Unger J
Acta Haematol. 1980;64(6):335-7. doi: 10.1159/000207314.
A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of water and electrolyte metabolism, mild renal failure and the patient's age could have contributed to the development of intoxication. Short-term lithium administration may be life-threatening and should thus be prescribed cautiously in hematological disorders as in other conditions.
一名74岁女性因药物性再生障碍性贫血接受碳酸锂治疗，每日3次，每次300毫克。8天后，她突然出现严重意识障碍，伴有肌阵挛和肌张力亢进，尽管停用了锂并输注了氯化钠，但这种情况持续了10天。轻微的水电解质代谢紊乱、轻度肾衰竭以及患者的年龄可能促使了中毒的发生。短期使用锂可能危及生命，因此在血液系统疾病以及其他情况下开具此药时都应谨慎。
