Kiessling W R, Pflughaupt K W, Haubitz I, Mertens H G
Acta Neurol Scand. 1980 Oct;62(4):255-8. doi: 10.1111/j.1600-0404.1980.tb03033.x.
Thyroid function was studied in 112 MS patients and 175 controls on the basis of T3, T4, T.B.G. and T.S.H. radioimmunoassays. In 33 MS patients with T.R.H. stimulation test was employed additionally. The MS patients had significantly increased T4 levels whereas T3 and T.S.H. were found to be significantly lower. No differences were found in the T.R.H.- stimulated T.S.H. response. The changes in thyroid function parameters were similar in different courses of MS and did not correlate with the degree of clinical disability. The results suggest that in MS the T4/T3 conversion might be reduced as seen in acute or chronic diseases. X
基于T3、T4、甲状腺素结合球蛋白（T.B.G.）和促甲状腺激素（T.S.H.）放射免疫测定，对112例多发性硬化症（MS）患者和175名对照者的甲状腺功能进行了研究。另外，对33例MS患者进行了促甲状腺激素释放激素（T.R.H.）刺激试验。MS患者的T4水平显著升高，而T3和T.S.H.水平显著降低。在T.R.H.刺激的T.S.H.反应方面未发现差异。甲状腺功能参数的变化在MS的不同病程中相似，且与临床残疾程度无关。结果表明，在MS中，如同在急性或慢性疾病中所见，T4/T3转化可能降低。X
