Safai B, Good R A
Arch Pathol Lab Med. 1977 Jun;101(6):327-31.
Basal cell carcinoma (BCC) is the most common form of skin cancer, accounting for 65% to 75% of all malignant skin tumors. Metastic BCC is very rare--only 109 documented cases have been reported to date. The mean time of survival after metastasis has been reported to be ten months. No effective therapeutic modality is known for its treatment. We are reporting a case of metastatic BCC in which we have found deficiency of cell-mediated immunity. Postmortem studies showed a co-existing squamous cell carcinoma in thelungs, brain, liver, and spleen. The most unusual finding in the postmortem study was evidence of juxtaposition of BCC and epidermoid carcinoma with distinct histologic dimorphism. We speculate that a combination of immunodeficiency and stromal independence is needed for metastases in BCC.
基底细胞癌（BCC）是最常见的皮肤癌形式，占所有恶性皮肤肿瘤的65%至75%。转移性基底细胞癌非常罕见——迄今为止仅报告了109例有记录的病例。据报道，转移后的平均生存时间为十个月。目前尚无有效的治疗方法。我们报告一例转移性基底细胞癌病例，其中发现细胞介导免疫缺陷。尸检研究显示，肺、脑、肝和脾同时存在鳞状细胞癌。尸检研究中最不寻常的发现是基底细胞癌与表皮样癌并列且具有明显组织学差异的证据。我们推测，基底细胞癌发生转移需要免疫缺陷和间质独立性共同作用。
