Matthews P N, Millis R R, Hayward J L
Br Med J (Clin Res Ed). 1981 Mar 7;282(6266):774-6. doi: 10.1136/bmj.282.6266.774.
The prognosis and clinical and pathological findings in 93 patients with breast cancer who had taken contraceptive steroids before diagnosis (study group) were compared with those in 93 control patients, also with breast cancer, matched for age and parity. The tumours in the women in the study group were found to have more favourable clinical and histological features than those in the control group. When only patients who had been treated by radical mastectomy were considered, those who had taken contraceptive steroids survived significantly longer even when differences in nodal state were taken into account. Significantly more patients in the study group had a family history of breast cancer. No evidence was found that taken oral contraceptive steroids had any harmful effect on tumour growth and spread, except possibly in patients with a close family history of breast cancer.
将93例在诊断前服用过避孕类固醇的乳腺癌患者（研究组）的预后以及临床和病理结果，与93例同样患有乳腺癌、年龄和产次相匹配的对照患者进行了比较。结果发现，研究组女性的肿瘤在临床和组织学特征方面比对照组的更有利。仅考虑接受根治性乳房切除术治疗的患者时，即使考虑到淋巴结状态的差异，服用过避孕类固醇的患者存活时间也显著更长。研究组中有家族乳腺癌病史的患者明显更多。没有发现证据表明服用口服避孕类固醇对肿瘤生长和扩散有任何有害影响，可能除了有乳腺癌家族病史的患者之外。
